hsc.criver.comHorseshoe Crab Conservation | Charles River
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Title:Horseshoe Crab Conservation | Charles River
Description:Charles River has helped alleviate pressures on horseshoe crab populations through conservation and animal welfare practices, as well as countless hours of research and development.
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This browser does not support video As keepers of the environment, we have a responsibility to preserve, protect and live harmoniously with the animals that share our planet. As a source of critical proteins that detect the presence of endotoxins in products and instruments used by humans, the Atlantic horseshoe crab has long been treasured by the biopharmaceutical industry. For this reason, it is critical that we serve as advocates for the humane treatment of these animals, and strive to achieve balance between our need for this valuable material and the livelihood of the animal that provides it. Charles River is proud to play a role in alleviating pressures on horseshoe crab populations through tireless conservation efforts, active animal welfare campaigns and decades of research and development. LIMULUS AMEBOCYTE LYSATE & ENDOTOXINS Resources Horseshoe crabs save our lives. What are we doing to help save theirs? Horseshoe crabs ensure the safety of every vaccine, pacemaker, and biomedical device in the United States with their bacteria-detecting blood. Researchers are now asking what we can do to save them from the increasing needs of the biomedical industry. Read More Thanks to the Power of Blue Blood In partnership with the South Carolina Aquarium’s Holland Lifelong Learning program, Norm Wainwright, Director of R&D at Charles River discussed why we owe our lives to the horseshoe crab and the significant role they play in our ecosystem. Read More Night at the Aquarium Tag teaming with the South Carolina Aquarium to learn more about the horseshoe crab population. Read More Conservation Initiatives for an Invaluable Partner Since endotoxins can be so toxic, any product or device that encounters bodily fluids is screened by Limulus amoebocyte lysate (LAL) reagents. John Dubczak, GM of Charles River Microbial Solutions explains the importance of conserving the source of this valuable reagent. Read More How Citizen Scientists Protect Horseshoe Crabs More than 2,500 individuals have participated in evening population counts, midnight tagging events, and marine debris removal activities all in the name of the horseshoe crab. Read More The ALARA Concept and Horseshoe Crab In recognition of the enormous value of LAL to world health, we must question if there is a need to limit the number of horseshoe crabs required to produce LAL. Read More From Horseshoe Crabs to the Depths of Space A Q&A with Mystic Aquarium Scientist-in-Residence and Charles River Senior Director of R&D Norm Wainwright. Read More Watching Horseshoe Crabs Grow Up Mystic Aquarium’s Rearing Project teaches Connecticut students how these ocean arthropods contribute to health and safety every day. Watch Now Ever Have an Injection? Thank a Horseshoe Crab Dr. Norman Wainwright talks about the importance of bacterial endotoxin testing and the role horseshoe crabs have in it. Read More Uncovering the Truth: Horseshoe Crabs, LAL & Alternative Methods Presented by Endotoxin Consultant and founder of Endosafe ® , Dr. James Cooper, this webinar will present key facts and published scientific data surrounding the species and the use of its blood in LAL. Watch the Webinar Tracking the Atlantic's Senior Citizen Horseshoe crabs keep us healthy, but how are they doing? Tagging operations are one way to find out. Read More The Importance of Horseshoe Crab Habitats These arthropods are found all along the Eastern seaboard, but their numbers are less abundant in New England and New York. Why? Read More Wading Deep For a long-term view of how future generations of horseshoe crabs will be able to cope and reproduce, one really needs to examine the gene pool. Read More Tales of the Horseshoe Crab Will the use of artificial bait help conserve American horseshoe crabs and stabilize their populations? Read More Mystic Aquarium & Charles River’s Horseshoe Crab Count Walk With a total of 88 horseshoe crabs counted, this year’s Mystic Aquarium Horseshoe Crab Counting Walk at Napatree Point in Westerly, RI was a huge success. Read More New England Aquarium and Charles River Presentation Living Fossils and Blue Blood: The Story of the Horseshoe Crab and Human Health Watch the Video Preserving the role of an ancient mariner This podcast discusses some of the earliest work undertaken in South Carolina to conserve horseshoe crabs and how it benefits us all. Listen to the Podcast Crab Conservation in South Carolina Biomedical manufacturers and conservationists alike have a vested interest in making sure these invertebrates continue to thrive and flourish. Find out how the species is faring. Read More The Most Noble Fishing There Is Eureka guest blogger, Jerry Gault, a longtime South Carolina fisherman, talks about his moral duty and legal responsibility to handle horseshoe crabs with care. Read More Adventures of Protecting the Horseshoe Crab John Dubczak talks about the importance of endotoxin testing in drug development. Read More An Ancient Animal's Blood is a Modern Medical Miracle At night, during the full and new moon in late May and early June, the sands of East Coast beaches host a dance that is a half-billion years old. Read More Remarkable Success Story of the Horseshoe Crab Learn about the horseshoe crabs’ remarkable story of survival and adaptability. Watch the Video Horseshoe Crabs Mate in Massive Beach "Orgy" Horseshoe crabs live in the ocean year-round, but they make one annual visit to the shoreline to lay eggs in sandy, wet beaches. Watch the Video Protecting an Ancient Mariner The Atlantic horseshoe crab has found allies in the biotech community. Find out why. Read More Though they look similar to crustaceans, they actually belong to the subphylum Chelicerata, relating them more closely to spiders and scorpions. Limulus polyphemus is found along the Atlantic and Gulf coasts from northern Maine to the Yucatán Peninsula, with the Delaware Bay as the center of the population. This interesting animal is important, not only for the pivotal role it plays in its ecosystems, but also for its valuable contribution to biomedical research applications. The true beauty of this remarkable creature, however, is seen in its primitive immune system. Instead of developing antibodies in response to infection, the immune system releases proteins that can bind and kill bacteria. In addition, other immune proteins clot when exposed to waterborne bacteria, a mechanism which forms the basis of the LAL test. CHARLES RIVER ADVOCACY We are committed to employing only fishermen licensed by the Department of Natural Resources to hand-harvest horseshoe crabs from the coastal waters of South Carolina. Our highly controlled and monitored procedures enable us to collect enough raw material for 24 months of LAL production from a minimum number of donor animals. Once the crabs are brought into our lab, they are carefully inspected by trained employees who determine the animal’s health and maturity. After careful collection of a measured amount of blood, the crabs are returned unharmed to their natural habitat within the same day, and their blood volume rebounds quickly. These practices have allowed Charles River to achieve an industry-leading survival rate of donor animals. Government Regulations Much of the continued survival of the horseshoe crab can be attributed to its inherent adaptability, as well as modern-day government protection. Prior to 1991, there were no laws or regulations in South Carolina dealing with horseshoe crabs. Increased fishing industry demands for Limulus polyphemus made it necessary to develop a state-wide management plan to conserve this resource. In 1992, Dr. James Cooper (a pioneer in the research and development of the LAL assay) wrote draft legislation that called for the management and regulation of horseshoe crab fisheries. 1 As a result, the South Carolina state legislature enacted laws to protect the indigenous horseshoe crab population. In South Carolina, horseshoe crabs mu...
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